Pyridoxal-5′-phosphate (P-5-P) is the bio-active form of vitamin B6, and is a catalyst for at least 113 known essential enzymatic reactions in the body. Studies show that people with compromised liver function and those with autism have an impaired ability to absorb conventional B6. Therefore, supplementing with P-5-P is imperative for these groups.

P-5-P is known to reduce levels of homocysteine, a toxic protein linked to heart disease, making it an important addition for anyone concerned about their cardiovascular health. Additionally, it is required for the production of serotonin and GABA, neurotransmitters that lift mood and provide a sense of calm. P-5-P is known to help alleviate symptoms of PMS, due to its ability to help balance hormones. It supports immune function in those who are critically ill, and pregnant women may benefit from its anti-nausea effects.